Acharya Prafulla Chandra College (APC College)

Acharya Prafulla Chandra College

Govt. Sponsored | NAAC Accredited A Grade College with CGPA 3.23

Affiliated to West Bengal State University

Acharya Prafulla Chandra College (APC College)

Dr. Madhushree Das Sarma

M.Sc., Ph.D.

Contact Details:

___________
Department of Chemistry
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Acharya Prafulla Chandra College, New Barrackpore, Kolkata-700131 West Bengal, India

Research Areas :

Medicinal Chemistry

Title of Ph.D. Thesis :

Bioactive Quinonoids from Plants and Their Synthetic Thesis Modification

List of Publications :

  • Antimycobacterial activity of diospyrin derivatives and a structural analogue of diospyrin against Mycobacterium tuberculosis in vitro, J. Antimicrob. Chemother. (2003), 51, 435-8.
  • Separation methods of quinonoid constituents of plants used in Oriental traditional medicines, J.Chromatogr. B (2003), 812, 259-75.
  • Development of a voltammetric sensor for diospyrin determination in nanomolar concentrations, Talanta, (2006), 68, 1378-83.
  • Cytotoxicity of diospyrin and its derivatives in relation to the generation of reactive oxygen species in tumour cells, in vitro and in vivo, Chemotherapy (2007), 53, 173-6.
  • Synthesis and antiproliferative activity of some novel derivatives of diospyrin, a 7 plant-derived naphthoquinonoid, Bioorg. Med. Chem. (2007), 15, 3672-7.
  • Novel glycoconjugates of diospyrin, a quinonoid plant product: synthesis and evaluation of cytotoxicity against human malignant melanoma (A375) and laryngeal carcinoma (Hep2), Org. Biomol. Chem. (2007), 5, 3115-25.
  • Synthesis of novel aminoquinonoid analogues of diospyrin and evaluation of their inhibitory activity against murine and human cancer cells, Eur. J. Med. Chem. (2008), 43, 1878-88.
  • Anti-inflammatory and anticancer compounds isolated from VentilagomadraspatanaGaertn.,Rubiacordifolia Linn. and Lantana camara Linn, J. Pharm. Pharmacol. (2010), 62, 1158-66.
  • HPLC of Quinonoid Phytochemicals' in High Performance liquid Chromatography in Phytochemical analysis, Editor(s): M. Waksmundzka-Hajnos& J. Sherma, C.R.C. Press, (2010),
  • Evaluation of a diospyrin derivative as antileishmanial agent and potential modulator of ornithine decarboxylase of Leishmaniadonovani, Exp. Parasitol. (2013), 135, 407-13.

Participation in Seminars/Workshops /Conferences etc.:

  • 'Synthesis of novel glycosylated derivatives of diospyrin, a naphthoquinonoid plant product.' M. Das Sarma, R. Ghosh, A. Patra and B. Hazra. International Conference on Natural Products: Chemistry, Technology & Medicinal Perspective, at Almaty, Kazakhstan, in October 8-11, 2003.
  • 'Synthesis of some novel amino derivatives of a naturally occurring bioactive quinone.' M. Das Sarma, R. Ghosh, A. Patra, K. Das and B. Hazra. National Symposium on
  • Organic Chemistry - II (NSOC-II): Current Trends and Prospects, at Kolkata, in December 17, 2003.
  • 'Studies on some amino derivatives of diospyrin, a naphthoquinonoid plant product.' M. Das Sarma, R. Ghosh, A. Patra and B. Hazra. 6th CRSI National Symposium, at Kanpur, in February 6-8, 2004.
  • Bioactive quinonoids: techniques for analysis and separation from plants.' M. Das Sarma, S. Basu and B. Hazra. National Conference on Medicinal Plants: Resources, Application and Conservation in India, at Kolkata, in February 11-12, 2005.
  • Antitumour activity of some indigenous medicinal plants: with special reference to their modulating effect on free radicals.' S. Basu, M. Das Sarma and B. Hazra. International Symposium on Free Radicals and Antioxidants in Health, Disease and Radiation & Vth National Conference of the Society of Free Radical Research-India, at Kolkata, in January 16-18, 2006.
  • 'Anticancer Activities of Diospyrin.' M.DasSarma. Relating Under Graduate Level Chemistry To Current Advances, at Krishnanagar Women's College, Nadia, in 28-29 September, 2013.